An Effort to Understand Ulcerative Colitis
Ulcerative colitis is an inflammatory bowel condition that affects around 100,000 people a year in the UK alone, and is thought to affect over 200 people per 100,000 in North America. Symptoms include losing weight, abdominal pain, frequent trips to the toilet and bloody diarrhea. Ulcerative colitis is a predominantly genetic disease.
In an effort to understand ulcerative colitis and find a new treatment for the condition, Dr. Andre Franke from the Albrechts University in Germany, along with colleagues from various universities around Europe, held a study to determine whether interleukin 10 (IL10) could possibly be helpful for ulcerative colitis. Interleukin 10 is an anti-inflammatory protein. After the study their initial assessment determined that interleukin 10 is a potential therapy, though more studies will be held. The study was published in Nature Genetics, a peer-reviewed scientific journal.
The study involved searching for exacting gene variations that would cause ulcerative colitis. To do this they obtained DNA samples from participants with ulcerative colitis, as well as DNA samples from a control group without the condition. They then analyzed and searched specific points along the DNA called SNPs - Single nucleotide polymorphisms – to determine whether certain variants are associated with the condition. The study was considered a genetic case-control study referred to as a genome-wide analysis. After doing analysis on over 2,000 people, they repeated the DNA test again on an additional 5,000 people from three other studies.
The researchers found that a variant of IL10 was present in some people with ulcerative colitis, as well as Crohn’s disease and some health controls. It appeared that the variant near to IL10 was responsible for a 35 percent increase in the chance of developing ulcerative colitis. When the study was completed they suggested that a defect in IL10 could be instrumental in developing the condition. They believe the study provides confirmation that variations within IL10 could be contributing to the condition, though more studies are needed to make a strong, solid conclusion. They do believe that interleukin 10 could be helpful if given to patients with colitis.
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In an effort to understand ulcerative colitis and find a new treatment for the condition, Dr. Andre Franke from the Albrechts University in Germany, along with colleagues from various universities around Europe, held a study to determine whether interleukin 10 (IL10) could possibly be helpful for ulcerative colitis. Interleukin 10 is an anti-inflammatory protein. After the study their initial assessment determined that interleukin 10 is a potential therapy, though more studies will be held. The study was published in Nature Genetics, a peer-reviewed scientific journal.
The study involved searching for exacting gene variations that would cause ulcerative colitis. To do this they obtained DNA samples from participants with ulcerative colitis, as well as DNA samples from a control group without the condition. They then analyzed and searched specific points along the DNA called SNPs - Single nucleotide polymorphisms – to determine whether certain variants are associated with the condition. The study was considered a genetic case-control study referred to as a genome-wide analysis. After doing analysis on over 2,000 people, they repeated the DNA test again on an additional 5,000 people from three other studies.
The researchers found that a variant of IL10 was present in some people with ulcerative colitis, as well as Crohn’s disease and some health controls. It appeared that the variant near to IL10 was responsible for a 35 percent increase in the chance of developing ulcerative colitis. When the study was completed they suggested that a defect in IL10 could be instrumental in developing the condition. They believe the study provides confirmation that variations within IL10 could be contributing to the condition, though more studies are needed to make a strong, solid conclusion. They do believe that interleukin 10 could be helpful if given to patients with colitis.
Return to:
Additional Posts
Social Security Disability and Morbid Obesity
Working and Applying for Social Security Disability
How to qualify for disability
Will I be approved by a disability judge?
Will Social Security Understand What My Medical Records Have to Say?
Can you get a second Social Security Disability Hearing if a judge denies you?
VA System Needs to be Updated
Social Security Disability SSI and Crohn's Disease
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