Gene Variants Important in Bowel Disorder
Could a gene be the culprit when it comes to ulcerative colitis? Dr. Andre Franke and his colleagues at the Christian-Albrechts University in Germany believe so; their study is at least enough to merit more studies that can show the same outcome. The case-controlled study was funded by the German Ministry of Education and Research (BMBF) and was published online in Nature Genetics, a peer-reviewed scientific journal.
It is thought that nearly 500,000 people in the United States suffer with Ulcerative colitis, an inflammatory bowel disease. There is no cure, but therapies can dramatically reduce the symptoms. The most common symptoms are bloody diarrhea and abdominal pain, but anemia, rectal bleeding, join pain, skin legions, weight loss and fatigue are also among the symptoms. The disease can occur at any age but is most likely to affect teens and young adults ages 15 to 30 years old and is also thought to be genetic.
In the study Dr. Franke and his colleagues were searching for gene variations that would make patients more susceptible to developing ulcerative colitis. The study consisted of 1,167 people with ulcerative colitis and 777 people without the disease. After obtaining DNA samples from all subjects, they looked at specific points in the DNA called SNPs to determine an association with the disease. Later, they did another test on 1,855 people with the disease and 3,091 control subjects without ulcerative colitis. During the testing, the researchers did not know which DNA belonged to which group.
What they found suggested that there is an association between ulcerative colitis and the gene interleukin 10 (IL10), which regulates inflammation. They found certain gene variants increased the chances of patients developing ulcerative colitis and also found that a defect in IL10 function is important to the development of the disorder.
More studies will need to be held to determine whether IL10 treatment will be helpful for those with ulcerative colitis, because the researchers still did not identify the actual variants that cause this and could not prove that the treatment could be helpful for those with ulcerative colitis. It may still take a number of years to find a solid conclusion, but trials should be easy to get underway with the conclusions of these studies.
Return to:
Social Security Disability Secrets
Social Security Disability Benefit Questions
Additional Posts
Social security definition of disability for SSD and SSI claims
Social security disability definition
How does social security define disability?
It is thought that nearly 500,000 people in the United States suffer with Ulcerative colitis, an inflammatory bowel disease. There is no cure, but therapies can dramatically reduce the symptoms. The most common symptoms are bloody diarrhea and abdominal pain, but anemia, rectal bleeding, join pain, skin legions, weight loss and fatigue are also among the symptoms. The disease can occur at any age but is most likely to affect teens and young adults ages 15 to 30 years old and is also thought to be genetic.
In the study Dr. Franke and his colleagues were searching for gene variations that would make patients more susceptible to developing ulcerative colitis. The study consisted of 1,167 people with ulcerative colitis and 777 people without the disease. After obtaining DNA samples from all subjects, they looked at specific points in the DNA called SNPs to determine an association with the disease. Later, they did another test on 1,855 people with the disease and 3,091 control subjects without ulcerative colitis. During the testing, the researchers did not know which DNA belonged to which group.
What they found suggested that there is an association between ulcerative colitis and the gene interleukin 10 (IL10), which regulates inflammation. They found certain gene variants increased the chances of patients developing ulcerative colitis and also found that a defect in IL10 function is important to the development of the disorder.
More studies will need to be held to determine whether IL10 treatment will be helpful for those with ulcerative colitis, because the researchers still did not identify the actual variants that cause this and could not prove that the treatment could be helpful for those with ulcerative colitis. It may still take a number of years to find a solid conclusion, but trials should be easy to get underway with the conclusions of these studies.
Return to:
Additional Posts
Social security definition of disability for SSD and SSI claims
Social security disability definition
How does social security define disability?
0 Comments:
Post a Comment
<< Home